Telomerase gets Wnt talking
نویسندگان
چکیده
منابع مشابه
Wnt Signaling: It Gets More Humorous with Age
In addition to its myriad of contributions in development, disease and regeneration, recent research implicates the Wnt/beta-catenin signaling cascade in yet another biological process - aging. The latest role of Wnt uncovers new complexities and opportunities for modulating the Wnt/beta-catenin pathway in regenerative medicine.
متن کاملWnt/b-Catenin Signaling Regulates Telomerase in Stem Cells and Cancer Cells
Telomerase activity controls telomere length and plays a pivotal role in stem cells, aging, and cancer. Here, we report a molecular link between Wnt/b-catenin signaling and the expression of the telomerase subunit Tert. b-Catenin–deficient mouse embryonic stem (ES) cells have short telomeres; conversely, ES cell expressing an activated form of b-catenin (b-cat) have long telomeres. We show that...
متن کاملMultiple Tumor Suppressor microRNAs Regulate Telomerase and TCF7, an Important Transcriptional Regulator of the Wnt Pathway
The human TERT (hTERT) gene encodes the telomerase catalytic subunit which plays a role in telomerase regulation. Telomerase is activated in more than 90% of all human malignancies and understanding how telomerase is regulated is necessary for implementation of successful anti-cancer therapies. microRNAs (miRNAs) are important regulators of gene expression in eukaryotic cells but evidence of th...
متن کاملWnt/β-Catenin Signaling Exacerbates Keloid Cell Proliferation by Regulating Telomerase.
OBJECTIVES Our goal was to investigate the relationship between keloid and telomerase as well as clarifying the influence of Wnt/β-catenin signaling on keloid cell proliferation. METHODS Tissues from 18 keloid patients were collected for further study. Keloid progenitor cells (KPC) and skin progenitor cells (SKP) were both included in this study. Lenti-virus transfection was used to divide ce...
متن کاملWnt/β-catenin signaling regulates telomerase in stem cells and cancer cells.
Telomerase activity controls telomere length and plays a pivotal role in stem cells, aging, and cancer. Here, we report a molecular link between Wnt/β-catenin signaling and the expression of the telomerase subunit Tert. β-Catenin-deficient mouse embryonic stem (ES) cells have short telomeres; conversely, ES cell expressing an activated form of β-catenin (β-cat(ΔEx3/+)) have long telomeres. We s...
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ژورنال
عنوان ژورنال: Nature Reviews Molecular Cell Biology
سال: 2009
ISSN: 1471-0072,1471-0080
DOI: 10.1038/nrm2739